The gut microbiome and its role in health, immune function and brain: how prebiotics, probiotics and fiber positively influence the microbiome.
The Gut Microbiome: Our Inner World
The human gut microbiome encompasses over 100 trillion microorganisms — more cells than the human body itself possesses. With a total weight of approximately 1.5 kg and over 1,000 different bacterial species (primarily Firmicutes and Bacteroidetes), it is one of nature's most complex ecosystems.
What the microbiome does:
- Digestion of fiber → production of short-chain fatty acids (SCFAs: butyrate, propionate, acetate)
- Synthesis of vitamins (K2, B12, folate, biotin)
- Development and regulation of the immune system (70% of immune cells reside in the gut)
- Protection against pathogens (colonization resistance)
- Communication with the brain via the Gut-Brain Axis
The Gut-Brain Axis: Gut as Second Brain
The gut contains approximately 500 million neurons (enteric nervous system) and is therefore called the "second brain." The bidirectional communication with the brain occurs through:
- Vagus nerve (direct neural channel)
- Neurotransmitters: Approximately 90–95% of the body's serotonin is produced in the gut
- Immune mediators: Cytokines that influence the CNS
- Metabolites: SCFAs and other microbial products that cross the blood-brain barrier
Dysbiosis (disrupted microbiome) correlates with:
- Depression and anxiety disorders
- ADHD and autism spectrum disorders
- Parkinson's disease (microbiome signatures visible years before clinical diagnosis)
Nutrition as the Most Powerful Microbiome Tool
Prebiotics: Food for Good Bacteria
Prebiotics are indigestible food components that selectively stimulate growth of health-promoting bacteria.
Key prebiotics and their sources: | Prebiotic | Sources | |---|---| | Inulin | Chicory, artichokes, onions, garlic | | FOS (Fructooligosaccharides) | Asparagus, bananas (unripe), leeks | | Beta-Glucan | Oats, barley, mushrooms | | Resistant Starch | Cooled potatoes, green bananas, cooked and cooled rice | | Pectin | Apples, berries, citrus fruits |
Probiotics: Introducing Live Bacteria
Probiotics are live microorganisms that confer health benefits in sufficient quantities.
Evidence-based applications:
- Lactobacillus rhamnosus GG — proven efficacy in traveler's diarrhea and antibiotic-associated diarrhea
- Bifidobacterium longum — improvement in irritable bowel syndrome
- Saccharomyces boulardii — in C. difficile infections and with antibiotic use
Natural probiotic sources:
- Natural yogurt, kefir, sauerkraut (naturally fermented, unpasteurized), tempeh, miso
Dysbiosis Triggers: What Harms the Microbiome
- Antibiotics: Drastic reduction in microbiome diversity, often months of recovery
- Ultra-processed foods: Emulsifiers (carrageenan, polysorbate 80) damage the intestinal mucosa
- Sugar-rich diet: Promotes Candida and pathogenic bacteria
- Chronic stress: HPA axis activation → altered gut motility and microbiome composition
- Sleep deprivation: Circadian dysregulation of the microbiome
Conclusion: The Microbiome as a Health Investment
A healthy gut microbiome is the foundation for immune health, mood, and metabolism. Nutrion analyzes your current fiber intake and creates a weekly plan with maximum microbiome benefit.